Glucose Metabolism of Human Skin
The Effects of Skin Composition on Glucose Sensing
Simulation of the response to an Oral Glucose Tolerance Test (OGTT).
Measured blood glucose is used as driving input for the model.
Spatio-temporal interstitial fluid (ISF) glucose kinetics for a slice in the dermis:
A more detailed simulation of 20 sec:
The multiphysics model was developed and simulated in COMSOL.
References
- Groenendaal W, Schmidt KA, von Basum G, van Riel NA, Hilbers PA. Diabetes Technol Ther. 2008 Aug;10(4):283-93. Modeling glucose and water dynamics in human skin. link to journal website / PubMed
- Groenendaal W, von Basum G, Schmidt KA, Hilbers PA, van Riel NA. J Diabetes Sci Technol. 2010 Sep 1;4(5):1032-40. Quantifying the composition of human skin for glucose sensor development. link to journal website / PubMed